Courtney T. Griffin

This study identifies TNF and endothelial IL-1R1 signaling as key drivers of capillary regression and fibrosis in obstructive kidney injury, showing that their combined inhibition preserves peritubular capillaries and reduces renal injury.

This study shows that endothelial RIPK3 reduces vascular permeability and inflammation in ischemia-reperfusion injury by regulating IL-6 secretion and adhesion molecule expression.

This study shows that overexpressing ERG in endothelial cells prevents vascular regression and neuronal damage in OIR models, suggesting ERG as a potential therapeutic target for retinopathies.

The paper shows that plasmin activity and sterile inflammation work together to cause lethal liver degeneration in embryos, and that reducing both improves liver health.

This study shows that endothelial PAR1/4 deletion increases insulin sensitivity and protects against diabetes by enhancing insulin receptor activity through reduced PTP1B activity.

This study investigates the role of protease-activated receptors 1 and 4 on hepatic endothelial cells during acetaminophen overdose, finding that low-expressing PAR4 is a potent receptor with functional redundancy to PAR1.

This study shows that BRG1 and CHD4 regulate endothelial extracellular matrix components through epigenetic mechanisms, essential for proper lung development in mice.

This study shows that CHD4 is essential for neonatal spermatogonia survival and gonad development by regulating Dmrt1 and Plzf expression.