Denis Wirtz

This study shows that E-cadherin upregulates the serine synthesis pathway in breast cancer cells, supporting proliferation and metastasis by providing metabolic precursors and resistance to oxidative stress.

The paper shows that breast cancer cell-derived small extracellular vesicles (EVs) become more adhesive and metastatic when produced in stiff matrices, promoting cancer spread through enhanced chemotaxis and fibroblast reprogramming.

This study introduces qMAP, a deep learning-based workflow for microanatomical mapping of human skin, identifying 10 core processes strongly associated with aging and achieving age prediction accuracy comparable to epigenetic clocks.

This paper uses a generative AI model to improve 3D tissue imaging by interpolating and restoring images, enhancing resolution and reducing artifacts across multiple modalities and species.

This study shows that substrate stiffness affects the development and strength of senescence features in fibroblasts, with mechanosensitive regulation of key biomarkers.

This paper develops velocity receptors (VRs) to enhance CAR T cell migration through solid tumors, improving tumor infiltration and survival.

This paper uses deep learning to label 17 kidney microstructures in 3D fetal rhesus macaque kidneys, revealing spatial relationships between glomeruli, arteries, and nephrons.

The paper develops a precision-engineered multi-compartment organoid model of the human fallopian tube validated against a 3D single-cell reference map.

This paper introduces SpaceMarkers, a method to infer molecular changes from cell-cell interactions in spatial transcriptomics data, applied to tumor-immune interactions in metastasis and immunotherapy.

The paper proposes a method to adjust p-values based on sample size to better detect differences in large datasets and reduce uncertainty in statistical decisions.

The paper identifies tissue morphology biomarkers in long-term PDAC survivors using digital pathology and machine learning, finding reduced heterogeneity and extra-tumoral space features correlate with better survival.