Systems BiologybioRxivPreprint
Accurate sequence-to-affinity models for SH2 domains from multi-round peptide binding assays coupled with free-energy regression
Dejan Gagoski, H. Tomas Rube, Chaitanya Rastogi…·Harmen J. Bussemaker
The paper develops a sequence-to-affinity model for SH2 domains using multi-round peptide binding assays and free-energy regression to predict binding specificity and variant effects.
DOI 10.1101/2024.12.23.630085