Tong Wang

Postsynaptic TAK1-GluN2B axis supports hippocampal synaptic integrity and cognitive function during aging

This study identifies a postsynaptic TAK1-GluN2B signaling axis that maintains synaptic integrity and cognitive function, with reduced TAK1 levels contributing to age-related hippocampal decline.

Axon Trafficking Counteracts Aberrant Protein Aggregation in Neurons

This study identifies ANXA7 as a critical adaptor for TIA1-containing RNP retrograde transport in axons, showing that its disruption leads to TIA1 aggregation and neurodegeneration.

Title: Cell-autonomous and non-cell-autonomous effects of TRIM72 on ALS disease progression

This study identifies TRIM72's protective role in ALS through both cell-autonomous and non-cell-autonomous mechanisms, showing its therapeutic potential in animal models and human patients.

Actomyosin-II Proactively Shields Axons of the Central Nervous System from Mild Mechanical Stress

The paper identifies actomyosin-II-driven radial contractility as a mechanism protecting central axons from mild mechanical stress and shows its protective role in a traumatic brain injury model.

Axons-on-a-Chip for Mimicking Non-Disruptive Diffuse Axonal Injury underlying Traumatic Brain Injury

The paper introduces an Axon-on-a-Chip model to mimic diffuse axonal injury and study its cellular responses under mechanical stress.

Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging

The paper uses super-resolution fluorescence imaging to reveal periodic CB1 receptor clusters in neurons and their interaction with the MPS.

Radial contractility of Actomyosin-II rings facilitates cargo trafficking and maintains axonal structural stability following cargo-induced transient axonal expansion

This study shows that actomyosin-II radial contractility regulates axonal cargo trafficking and structural stability by controlling transient radial expansion during cargo transport.