Adrien Guillot

Hepatocyte-, but not myeloid cell-Rictor/mTORC2 deficiency moderately attenuates steatotic liver disease induced by intake of a choline-deficient, amino acid-defined high-fat diet

This study shows that hepatocyte-specific mTORC2 deficiency slightly reduces liver disease from a choline-deficient diet, while myeloid cell deficiency has no effect.

2D, or not 2D? Investigating Vertical Signal Integrity of Tissue Slices

This paper introduces a tool to detect overlapping cells and segmentation errors in 3D spatial transcriptomics data.

Neonatal liver niches program T cell tolerance

The paper identifies a neonatal liver program that expands regulatory T cells while limiting conventional T cell activation, influencing susceptibility to viral infections and protection against liver disease.

The adhesion molecules β7 integrin and L-selectin contribute to cholestatic liver disease in male mice

This study shows that β7 integrin and L-selectin contribute to DDC-induced cholangiopathy in male mice by promoting immune cell infiltration, gut barrier dysfunction, and microbiota shifts.

Fetal Liver-like Organoids Recapitulate Blood-Liver Niche Development and Multipotent Hematopoiesis from Human Pluripotent Stem Cells

Multiomics analyses decipher intricate changes in the cellular and metabolic landscape of steatotic livers upon dietary restriction and sleeve gastrectomy

This study uses multi-omics approaches to analyze how dietary restriction and sleeve gastrectomy affect the cellular and metabolic changes in steatotic livers in rats and humans.