Pharmacology & ToxicologyProceedings of the National Academy of SciencesPeer-reviewed
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12/15-Lipoxygenase orchestrates murine wound healing via PPARg-activating oxylipins acting holistically to dampen inflammation.
Christopher P. Thomas, Victoria J. Tyrrell, James J. Burston…·Valerie B. O’Donnell
Alox15-deficient mice heal skin punch wounds with excess collagen, low matrix metalloproteinase activity and unresolved inflammatory gene expression; topical physiological 12/15-lipoxygenase oxylipin mixtures reduced collagen and raised collagenase activity.
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