Author
Cardiff UniversityORCID 0000-0003-4699-6205Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Alicia Derrac Soria, David Gregory Hill, Stuart T. O. Hughes…·Simon A. Jones
The paper identifies distinct cytokine signaling networks in mouse models of arthritis that mirror human RA synovial pathotypes, revealing molecular mechanisms underlying disease heterogeneity.
Christopher P. Thomas, Victoria J. Tyrrell, James J. Burston…·Valerie B. O’Donnell
Alox15-deficient mice heal skin punch wounds with excess collagen, low matrix metalloproteinase activity and unresolved inflammatory gene expression; topical physiological 12/15-lipoxygenase oxylipin mixtures reduced collagen and raised collagenase activity.
Daniela O. Costa, Stuart T.O Hughes, Robert L. Jenkins…·Valerie B. O’Donnell
This study identifies IL-6's role in elevating thrombosis in RA via platelet 12-lipoxygenase-generated pro-coagulant phospholipids.
Alicia Derrac Soria, Myles Lewis, Xiao Liu…·Simon A. Jones
The paper identifies CRTAM-expressing CD4+ T-cells in lymphoid-driven synovitis and shows that IL-6 and IL-27 inhibit their activation through STAT3 and ZEB1.