BiochemistryChemical Biology & Drug DesignPeer-reviewed
In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.
Vini D. Meshram, Ramkumar Balaji, Preethi Saravanan…·Basant Kumar Patel
This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.
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