Himanshu Joshi

SketchDNA provides a GUI tool for creating multiscale DNA models, enabling simulations of topological DNA structures and their dynamics.

This study investigates the unfolding mechanism of TDP-43's mitochondrial localization sequence M1 and identifies a potential inhibitor, ZINC73240059, that binds M1 to block TDP-43's aberrant mitochondrial localization in ALS.

The paper identifies a residue-specific dominant-negative ubiquitin mutant that selectively inhibits Ubp14 deubiquitinase activity, revealing functional selectivity in proteostasis regulation.

This paper introduces Stack-pPAINT, a super-resolution imaging technique using DNA base-stacking interactions to detect proximal target molecules, demonstrating its application in visualizing microtubular structures.

This study identifies vitamin D3 as a potential inhibitor of TDP-43's mitochondrial mis-localization through molecular docking and simulation of the M3 region.

This paper demonstrates DNA branch migration across lipid membranes to detect intracellular RNA without lysing cells, using a synthetic GPCR-like system called HALOS.

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

The paper designs DNA nanochannels that allow small molecules to diffuse through micron-length channels, demonstrating controlled transport between compartments.

This study shows that DNA-based ion channels with continuous backbones form more stable and efficient pores in lipid membranes than those with nicks.