Author

Ramkumar Balaji

Indian Institute of Technology HyderabadORCID 0000-0003-0476-2451Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Approach:mixed model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Basant Kumar PateliD· 3 shared Himanshu JoshiiD· 3 shared Akarsh BajpaiiD· 1 shared Anamika BhargavaiD· 1 shared Jessica BaaiD· 1 shared Preethi SaravananiD· 1 shared Shanu BhardwajiD· 1 shared Vini D. Meshram· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

Basant Kumar PatelORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

BiophysicsbioRxivPreprintJun 17, 2026

Mechanistic Insights into Unfolding of the Mitochondrial Localization Sequence M1 of TDP-43 and Identification of a MAPKAPK2 Inhibitor as a potential binder of M1 for inhibition of TDP-43's Aberrant Mitochondrial Localization

Ramkumar Balaji, Shanu Bhardwaj, Jessica Baa…·Basant Kumar Patel

This study investigates the unfolding mechanism of TDP-43's mitochondrial localization sequence M1 and identifies a potential inhibitor, ZINC73240059, that binds M1 to block TDP-43's aberrant mitochondrial localization in ALS.

DOI 10.64898/2026.06.17.732848

humanproteomics

𝕏 PostBluesky

BioinformaticsbioRxivPreprintNov 13, 2025

Elucidating the conformational dynamics of the mitochondrial localization signal, M3, of TDP-43 and accessing potential inhibitors using molecular docking and simulation

Ramkumar Balaji, Himanshu Joshi, Basant Kumar Patel

This study identifies vitamin D3 as a potential inhibitor of TDP-43's mitochondrial mis-localization through molecular docking and simulation of the M3 region.

DOI 10.1101/2025.11.13.688389

humanprotein structure

𝕏 PostBluesky

BiochemistryChemical Biology & Drug DesignPeer-reviewedOct 1, 2024

In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.

Vini D. Meshram, Ramkumar Balaji, Preethi Saravanan…·Basant Kumar Patel

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

8 citations

humanprotein structure

𝕏 PostBluesky