Author

Preethi Saravanan

Indian Institute of Technology HyderabadORCID 0000-0002-5399-872XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Basant Kumar PateliD· 2 shared Akarsh BajpaiiD· 1 shared Anamika BhargavaiD· 1 shared Himanshu JoshiiD· 1 shared Priyadarshini Veerabhadraswamy· 1 shared Ramkumar BalajiiD· 1 shared Vidhya BharathiiD· 1 shared Vini D. Meshram· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

Basant Kumar PatelORCID

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2 papers

Recent·Most cited

BiochemistryNew Journal of ChemistryPeer-reviewedJan 1, 2025

Enhanced in vitro aggregation, but not phase separation, of TDP-43 and its C-terminal fragments generate deep-blue autofluorescence.

Preethi Saravanan, Vidhya Bharathi, Priyadarshini Veerabhadraswamy, Basant Kumar Patel

This study shows that enhanced in vitro aggregation of TDP-43 and its fragments generates deep-blue autofluorescence, which is not emitted by phase-separated structures or oligomers.

2 citations

proteomicsexperimental assay

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BiochemistryChemical Biology & Drug DesignPeer-reviewedOct 1, 2024

In silico and in vitro studies suggest epigallocatechin gallate (EGCG), a polyphenol in green tea, can bind and modulate the aggregation and cytotoxicity of the full-length TDP-43 protein implicated in TDP-43 proteinopathies.

Vini D. Meshram, Ramkumar Balaji, Preethi Saravanan…·Basant Kumar Patel

This paper shows EGCG inhibits TDP-43 aggregation and cytotoxicity in vitro through binding to its C-terminal domain.

8 citations

humanprotein structure

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