Author

Nathan J. Spix

Van Andel InstituteORCID 0000-0001-6222-0701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

Hui SheniD· 2 shared Peter W. LairdiD· 2 shared Toshinori HinoueiD· 2 shared Wanding ZhouiD· 2 shared Alexandra VanderArk· 1 shared Ashley K. WisemaniD· 1 shared Benjamin K. JohnsoniD· 1 shared Bret Barnes· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersGenomics

Hui ShenORCID

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2 papers

Recent·Most cited

GenomicsNature CommunicationsPeer-reviewedJul 7, 2025

High-coverage allele-resolved single-cell DNA methylation profiling by scDEEP-mC reveals cell lineage, X-inactivation state, and replication dynamics

Nathan J. Spix, Walid Abi Habib, Zhouwei Zhang…·Peter W. Laird

The paper introduces scDEEP-mC, a single-cell DNA methylation profiling method, and shows it can identify cell types, X-inactivation states, and replication dynamics with high coverage.

9 citations

humanDNA methylation

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GenomicsCell GenomicsPeer-reviewedJul 1, 2022

DNA Methylation Dynamics and Dysregulation Delineated by High-Throughput Profiling in the Mouse

Wanding Zhou, Toshinori Hinoue, Bret Barnes…·Peter W. Laird

This paper develops a high-throughput DNA methylation array and atlas for mice, revealing tissue-specific methylation patterns and their associations with aging, differentiation, and disease.

120 citationstop 1%

mouseDNA methylation

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