Author

Sainath Polepalli

Indian Institute of Science BangaloreORCID 0000-0001-6239-7558Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1

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Organism:bacteria (other)· 1 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

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Amit SinghiD· 1 shared Anupam RoyiD· 1 shared Bapan MondaliD· 1 shared Somnath DuttaiD· 1 shared

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2025-2025 · peak 1/yr

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4 top collaborators · 6 mutual co-author links

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1 shared paperBiophysics

Amit SinghORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintJul 3, 2025

Molecular insights into inhibitor action on a key bacterial metabolic enzyme Cystathionine β-Synthase

Sainath Polepalli, Anupam Roy, Bapan Mondal…·Somnath Dutta

This paper investigates the molecular mechanism of aminooxyacetic acid (AOAA) inhibition of MtbCBS, a key bacterial enzyme, using cryo-EM and computational methods, revealing critical residues and structural factors for irreversible inhibition.

DOI 10.1101/2025.07.03.662948

bacteria (other)structural biology

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