This paper investigates the molecular mechanism of aminooxyacetic acid (AOAA) inhibition of MtbCBS, a key bacterial enzyme, using cryo-EM and computational methods, revealing critical residues and structural factors for irreversible inhibition.

bioRxiv · Jul 3, 2025 · PreprintBiophysics

Immunogenicity and Structure of a Stabilized HIV -1 clade C Env from a Pediatric Elite neutralizer in Complex with an Autologous bnAb

Swarandeep Singh, Sanjeev Kumar, Arnab Chatterjee, Lakshay Malhotra, Muneeb Pervez, Abdul Rahman, Ifrah Andrabi, Bapan Mondal, Sanket Katpara, Shaifali Sharma, Harsh Bhakri, Anjli Gaur, Tanu Bansal, V. N. Iyer, Abdul Wahid Hussain, , Kalpana Luthra

This study investigates the immunogenicity and structure of a clade C HIV-1 Env trimer from a pediatric elite-neutralizer, showing it elicits strong autologous neutralizing antibodies and reveals key neutralizing epitopes.

bioRxiv · Apr 26, 2025 · PreprintImmunology

Crosstalk between plasma membrane and Staphylococcus α-hemolysin during oligomerization

Arnab Chatterjee, Anupam Roy, Thejas Satheesh, Debajyoti Chakraborty, Partho Pratim Das, Bapan Mondal, Prithiv Kishore, Bartika Ghoshal, Siddharth Jhunjhunwala, Mahipal Ganji, Somnath Dutta

This study investigates the structural and functional dynamics of Staphylococcus aureus α-hemolysin during membrane interaction, revealing its role in cell necrosis and pore formation.

bioRxiv · May 11, 2024 · PreprintBiophysics