Somnath Dutta

Extracellular vesicle-bound bacterial toxin pneumolysin triggers membrane engagement and damage beyond canonical pore formation

This study shows that pneumolysin, a bacterial toxin, can damage target cell membranes through vesicle fusion rather than pore formation.

Development of a thermostable and broadly neutralizing pan-sarbecovirus vaccine candidate

This paper develops a thermostable, broadly neutralizing pan-sarbecovirus vaccine candidate using stabilized RBD derivatives from multiple sarbecovirus clades, showing enhanced thermal stability and immunogenicity in mice.

Cryo-EM reveals the structural heterogeneity and conformational flexibility of multidrug efflux pumps MdtB and MdtF

The paper uses cryo-EM to determine the structures of MdtB and MdtF, revealing structural and functional differences among HAE-RND pumps.

Membrane curvature during membrane rupture and formation of pentagonal pyramidal superassemblies by a pore-forming toxin, Vibrio cholerae Cytolysin, using single particle cryo-EM

This study uses cryo-EM to show how Vibrio cholerae Cytolysin induces membrane curvature and forms superassemblies during membrane rupture.

Molecular insights into inhibitor action on a key bacterial metabolic enzyme Cystathionine β-Synthase

This paper investigates the molecular mechanism of aminooxyacetic acid (AOAA) inhibition of MtbCBS, a key bacterial enzyme, using cryo-EM and computational methods, revealing critical residues and structural factors for irreversible inhibition.

Immunogenicity and Structure of a Stabilized HIV -1 clade C Env from a Pediatric Elite neutralizer in Complex with an Autologous bnAb

This study investigates the immunogenicity and structure of a clade C HIV-1 Env trimer from a pediatric elite-neutralizer, showing it elicits strong autologous neutralizing antibodies and reveals key neutralizing epitopes.

Crosstalk between plasma membrane and Staphylococcus α-hemolysin during oligomerization

This study investigates the structural and functional dynamics of Staphylococcus aureus α-hemolysin during membrane interaction, revealing its role in cell necrosis and pore formation.