Matthew Hackbart

This study shows that viral replication byproducts called cbVGs drive changes in circadian gene expression during infection through distinct immune pathways, with ARNTL2 playing a key role in amplifying antiviral responses.

The paper shows that terminal loop sequences in viral double-stranded RNAs enhance RIG-I signaling and IFN expression, with synthetic versions triggering innate immune responses in mice.

VODKA2 detects non-standard viral genomes from RNA-seq data using an HPC-optimized pipeline.