Author

Evgenii Ziaikin

Hebrew University of JerusalemORCID 0000-0001-6316-1301Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Masha Y. NiviD· 3 shared Alon RainishiD· 2 shared Einav MalachiD· 2 shared Nitsan DallaliD· 2 shared Shir EyaliD· 2 shared Gil Daniel Paz· 1 shared Lior PeriiD· 1 shared Noga Nir-Marom· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Masha Y. NivORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 27, 2026

Where do the ligands bind? Co-folding bitter taste GPCRs with the BitterDB chemical space

Evgenii Ziaikin, Masha Y. Niv

The paper evaluates the Boltz-2 co-folding framework to predict ligand binding pockets in TAS2R GPCRs and identifies sequence features that determine pocket preference.

DOI 10.64898/2026.06.26.734512

humancryo-EM

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Pharmacology & ToxicologybioRxivPreprintJun 22, 2026

Pharmaceutical TAS2R14 Agonists Display Diverse Potency, Efficacy, and Binding-Site Sensitivity

Shir Eyal, Nitsan Dallal, Alon Rainish…·Masha Y. Niv

The paper examines how three pharmaceutical drugs activate TAS2R14 through different binding modes and efficacy, using cell-based assays and receptor mutations.

DOI 10.64898/2026.06.17.732860

humanproteomics

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BiochemistryCellular and Molecular Life SciencesPeer-reviewedMar 30, 2026

Intracellular and Dual-Site Inhibition of a bitter taste GPCR

Nitsan Dallal, Gil Daniel Paz, Noga Nir-Marom…·Masha Y. Niv

The paper investigates the inhibitory mechanisms of TAS2R14 antagonists by analyzing mutations and computational models, revealing distinct binding sites and potencies.

3 citationstop 1%

experimental assay

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