Author

Chad Leidy

Universidad de Los AndesORCID 0000-0001-6331-8399Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Approach:mixed model· 1

Frequent Co-Authors

Marcela Manrique-MorenoiD· 4 shared Chiara CarazzoneiD· 3 shared Elizabeth Suesca· 3 shared Carolina Muñoz-CamargoiD· 2 shared Gerson-Dirceu LópeziD· 2 shared Adriana Marcela Celis RamíreziD· 1 shared Alejandro CifuentesiD· 1 shared Andres Ballesteros· 1 shared

Activity by Year

2026-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiophysics

Marcela Manrique-MorenoORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Staphylococcus aureus carotenoid staphyloxanthin modifies the structure of phosphatidylglycerol lipid bilayers

David Ricardo Figueroa Blanco, Andres Ballesteros, Julián M. Delgado, Juan David Orjuela, John E. Cabrera, Logan Hartmann, Jad Jaber, Kevin Ji, Lucy Knox, Elizabeth Suesca, Gerson-Dirceu López, Chiara Carazzone, Marcela Manrique-Moreno, Gian Pietro Miscione, Stephanie Tristram‐Nagle, , Camilo A. Aponte-Santamaria

This study investigates how staphyloxanthin modifies phosphatidylglycerol lipid bilayers using simulations and experiments, revealing structural changes that enhance membrane stability.

bioRxiv · Oct 6, 2026 · PreprintBiophysics

Assessing the translation of AI-prioritized genome-derived peptide fragments into validated antimicrobial candidates

Sebastian Ojeda, Paula Avila, Stiven Castellanos, Paloma Lemaitre, Valeria Ruiz-Ramírez, Marcela Manrique-Moreno, Adriana Marcela Celis Ramírez, Pablo Arbeláez, Chad Leidy, Carolina Muñoz-Camargo

This study evaluates AI-prioritized antimicrobial peptides derived from Malassezia furfur genomes, showing their antimicrobial activity and highlighting AI prediction biases.

bioRxiv · Aug 26, 2026 · PreprintBioengineering

Exposure to the antimicrobial peptides LL-37 and ATRA-1 induces a lipidome response in Staphylococcus aureus that alters membrane biophysical properties

Christian Fuertes, Juan E. Gonzalez, Elizabeth Suesca, Paula Guzmán-Sastoque, Carolina Muñoz-Camargo, Marcela Manrique-Moreno, Chiara Carazzone, Chad Leidy

This study investigates how antimicrobial peptides LL-37 and ATRA-1 alter lipid composition and membrane biophysical properties in Staphylococcus aureus, revealing peptide-specific lipid remodeling responses.

Biochimica et Biophysica Acta (BBA) - Biomembranes · Jun 16, 2026Peer-reviewedBiophysics

Membrane structural properties in Staphylococcus aureus are tuned by the carotenoid 4,4'-diaponeurosporenoic acid

Jessica Múnera-Jaramillo, Gerson-Dirceu López, Elizabeth Suesca, Elena Ibáñez, Alejandro Cifuentes, Chiara Carazzone, Chad Leidy, Marcela Manrique-Moreno

This study investigates how 4,4'-DNPA, a carotenoid in S. aureus, affects membrane biophysical properties, showing it increases membrane order and stability compared to STX.

Biochimica et Biophysica Acta (BBA) - Biomembranes · May 18, 2026Peer-reviewedBiophysics