Design of facilitated dissociation enables control over cytokine signaling duration
Adam J. Broerman, Christoph Pollmann, Yang Zhao, Mauriz A. Lichtenstein, Mark D. Jackson, Maxx H. Tessmer, Won Hee Ryu, Masato Ogishi, Mohamad H. Abedi, Danny D. Sahtoe, Aza Allen, Alex Kang, Joshmyn De La Cruz, Evans Brackenbrough, Banumathi Sankaran, , David A. Baker
The paper designs proteins with controlled dissociation rates by introducing strained excited states, enabling rapid cytokine receptor dissociation.
Nature · Sep 24, 2025Peer-reviewedBiochemistry