Mohamad H. Abedi

This paper designs a chemically induced dimerization system using a de novo macrocycle and protein homodimer to control cellular processes.

This paper demonstrates that AI-designed receptor modulators can drive efficient human fibroblast-to-muscle transdifferentiation by rewiring extracellular signaling.

The paper designs novel cytokines by fusing computationally generated receptor-binding domains, identifying several that activate signaling pathways and have specific biological effects.

This paper designs synthetic cytokine agonists with controlled receptor geometry to modulate signaling outcomes and functional effects.

This paper designs a synthetic ligand, H2F, that induces HER2-FGFR proximity to reprogram fibroblasts into myogenic cells and promote myogenic regeneration.

The paper designs proteins with controlled dissociation rates by introducing strained excited states, enabling rapid cytokine receptor dissociation.

This paper designs a thermal bioswitch to control macrophage activation in vivo, enabling spatially localized gene expression for at least 14 days after ultrasound heating.

This paper introduces SNIPR, a synthetic receptor that responds to soluble ligands, enabling targeted CAR T-cell therapy and synthetic cell signaling.

This paper develops a non-invasive ultrasound-based method to track cell-based therapies using acoustic reporter genes in primary mammalian cells.

The paper designs EndoTags to trigger endocytosis and degradation of target proteins, enabling tissue-specific targeting and therapeutic applications.

The paper fine-tunes AlphaFold to predict peptide binding specificity for MHC and other domains, achieving performance comparable to sequence-based methods.

This paper develops a method to control therapeutic bacteria using focused ultrasound to target tumor sites and release immune checkpoint inhibitors, effectively suppressing tumor growth.