Daniel Z. Radecki

This paper describes Wobbly hedgehog syndrome as a progressive neurodegenerative disease characterized by demyelination, remyelination, axonal degeneration, and neuronal loss, similar to progressive multiple sclerosis.

The paper shows Gli2 is essential for migration of ventral neural stem cells to demyelinated lesions and their differentiation into oligodendrocytes, highlighting the non-redundant roles of Gli1 and Gli2 in remyelination.