Jayshree Samanta

This paper describes Wobbly hedgehog syndrome as a progressive neurodegenerative disease characterized by demyelination, remyelination, axonal degeneration, and neuronal loss, similar to progressive multiple sclerosis.

This study identifies Gli1's role in regulating endoneurial architecture in peripheral nerves, showing it functions independently of Dhh and is required for maintaining nerve structure.

The paper analyzes transcriptomic changes in Gli1-deficient neural stem cells during demyelination to identify mechanisms enhancing remyelination.

The paper shows Gli2 is essential for migration of ventral neural stem cells to demyelinated lesions and their differentiation into oligodendrocytes, highlighting the non-redundant roles of Gli1 and Gli2 in remyelination.