Shubham Das

This study identifies VgrG1-ACD as a bacterial target of Vibrio cholerae's T6SS effector, showing it binds and disrupts E. coli MreB, altering morphology and growth without crosslinking.

This study identifies FNBP4 as a nuclear actin-binding protein that inhibits formin FMN1, revealing its dual role in regulating nuclear actin dynamics.

This study identifies a novel interaction between Dvl2 and profilin2, revealing that profilin2 binds to the extreme-C-terminus of Dvl2 independently of the PDZ or DEP domains and remains active even when Dvl2 is autoinhibited.

This study identifies FNBP4 as a regulator of FMN1-mediated actin dynamics, showing it inhibits actin assembly and bundling by interacting with FMN1 domains and localizing to the nucleus.