Danni A. Gadd

The paper develops epigenetic scores for GDF15 and NT-proBNP levels, showing associations with disease risks and brain health traits in two cohorts.

This study identifies gene-environment interactions affecting plasma proteins in UK Biobank, discovering 683 vQTLs and over 1,400 GEIs across 571 proteins.

The paper uses gene editing to tag eEF1A2 in mice, revealing its early embryonic expression and distinct subcellular localization compared to eEF1A1 in neurons.

The paper refines epigenetic predictors of chronological and biological age using large-scale EWAS and external validation, improving cAge prediction and outperforming existing bAge predictors.

The paper conducts blood-based epigenome-wide association studies on 19 disease states, identifying novel CpG-disease associations and highlighting poor replication in existing literature.

The paper identifies DNA methylation and proteomic markers associated with brain health through integrated methylome and phenome analyses.

This study identifies DNA methylation predictors of cognitive function using blood samples, showing they explain variance in cognitive ability and associate with biological markers.

The paper develops epigenetic scores (EpiScores) for plasma proteins to predict disease risk, finding 137 associations with incident morbidities independent of known factors.

The paper identifies genetic and epigenetic factors influencing plasma protein levels linked to Alzheimer's disease, finding novel associations with TREM2 and TBCA.

The paper applies blood-derived epigenetic predictors of lifestyle traits to brain samples, finding variable correlations across brain regions and a strong link between smoking and the dorsolateral prefrontal cortex.

The paper develops a DNA methylation-based proxy for interleukin-6 and finds it correlates with age and cognitive functioning better than serum IL-6.