Kathryn Louise Evans

Data Resource Profile: Whole Blood DNA Methylation Resource in Generation Scotland (MeGS)

The paper describes a large DNA methylation dataset from the Generation Scotland cohort, providing methylation profiles and associated phenotypes for research purposes.

A blood- and brain-based EWAS of smoking

The paper conducts a Bayesian EWAS and GWAS of smoking using DNA methylation data from blood and brain tissues, identifying smoking-related loci and developing an epigenetic biomarker.

DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

The paper develops epigenetic scores for GDF15 and NT-proBNP levels, showing associations with disease risks and brain health traits in two cohorts.

Blood-based DNA methylation study of alcohol consumption

This paper develops an epigenetic score to objectively measure alcohol consumption using blood-based DNA methylation and validates it across multiple cohorts, finding associations with brain health metrics.

Methylome-wide association studies of traumatic injury identifies differential DNA methylation of synaptic plasticity and GABAergic-signalling.

The paper identifies differential DNA methylation patterns associated with traumatic injury in individuals with MDD compared to controls, highlighting synaptic plasticity and GABAergic-signalling pathways.

Development and validation of DNA Methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes

Refining epigenetic prediction of chronological and biological age

The paper refines epigenetic predictors of chronological and biological age using large-scale EWAS and external validation, improving cAge prediction and outperforming existing bAge predictors.

Phenome-wide analysis identifies parent-of-origin effects on the human methylome associated with changes in the rate of aging

The paper identifies parent-of-origin effects on the methylome linked to aging rates by analyzing CpG methylation in a large family cohort.

Morphological profiling by cell painting in human neural progenitor cells classifies hit compounds in a pilot drug screen for Alzheimer's disease

The paper uses cell painting to identify drugs that reverse SORL1 deletion phenotypes in neural progenitor cells, revealing potential therapeutic targets for Alzheimer's disease.

Blood-based epigenome-wide analyses on the prevalence and incidence of nineteen common disease states

The paper conducts blood-based epigenome-wide association studies on 19 disease states, identifying novel CpG-disease associations and highlighting poor replication in existing literature.

Local CpG density affects the trajectory of age-associated epigenetic changes

The paper shows that local CpG density influences age-related DNA methylation changes in humans by analyzing longitudinal methylation data and SNP data from 600 individuals.

Characterisation and Genetic Architecture of Major Depressive Disorder Subgroups Defined by Weight and Sleep Changes

This study characterizes MDD subgroups based on weight and sleep changes, finding distinct clinical and genetic profiles, including novel associations with epilepsy and immunometabolic genes.

Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

The paper identifies DNA methylation and proteomic markers associated with brain health through integrated methylome and phenome analyses.

Epigenetic markers of adverse lifestyle identified among night shift workers

This study identifies epigenetic markers associated with night shift work, showing links to BMI, education, smoking, and accelerated biological aging.

The influence of biological and statistical properties of CpGs on epigenetic predictions of eighteen traits

This study evaluates how biological and statistical properties of CpGs affect epigenetic predictions for eighteen traits, showing that CpG methylation QTL status and beta-value distribution influence prediction accuracy.

Genetic control of KRAB-ZFP genes explains distal CpG-site methylation which associates with human disease phenotypes.

The paper identifies KRAB-ZFP genes' influence on CpG-site methylation and links these methylation patterns to disease phenotypes like rheumatoid arthritis and HIV infection.

Blood-based epigenome-wide analyses of cognitive abilities

This study identifies DNA methylation predictors of cognitive function using blood samples, showing they explain variance in cognitive ability and associate with biological markers.

Epigenetic scores for the circulating proteome as tools for disease prediction

The paper develops epigenetic scores (EpiScores) for plasma proteins to predict disease risk, finding 137 associations with incident morbidities independent of known factors.

Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk

The paper identifies genetic and epigenetic factors influencing plasma protein levels linked to Alzheimer's disease, finding novel associations with TREM2 and TBCA.

Lifestyle and Genetic Factors Modify Parent-of-Origin Effects on the Human Methylome

This study identifies modifiable parent-of-origin effects on DNA methylation by analyzing genetic and environmental factors in a large cohort.

Loss of SORCS2 is associated with neuronal DNA double-strand breaks

This study shows that loss of SORCS2 increases DNA double-strand breaks in neurons, linking it to neurodegenerative processes.

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

This study investigates the relationship between early life stressors and adult mental health through methylome-wide association studies, finding no evidence of methylome mediation but linking birth date to blood cell type composition.

Genome-wide methylation data improves dissection of the effect of smoking on body mass index.

This study uses genome-wide methylation data to assess the impact of smoking and gene-smoking interactions on obesity-related traits, showing improved variance explanation compared to traditional methods.

Creating and validating a DNA methylation-based proxy for Interleukin-6

The paper develops a DNA methylation-based proxy for interleukin-6 and finds it correlates with age and cognitive functioning better than serum IL-6.

Epigenetic clocks predict prevalence and incidence of leading causes of death and disease burden

This study shows that DNAm GrimAge predicts disease incidence and prevalence better than other epigenetic clocks in a large cohort.

Characterisation of an inflammation-related epigenetic score and its association with cognitive ability

The paper develops an epigenetic CRP score to assess chronic inflammation and its link to cognitive ability, finding it more consistently associated with cognition than serum CRP across two cohorts.

DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

DNA methylation outlier burden, health and ageing in Generation Scotland and the Lothian Birth Cohorts of 1921 and 1936.

This study examines DNA methylation outlier burden as a marker of biological age and finds it increases with age but is not strongly linked to health outcomes or survival.

Birth weight predicts psychiatric and physical health, cognitive function, and DNA methylation differences in an adult population

This study links birth weight to adult health outcomes and DNA methylation differences, identifying a significant CpG site and associations with biological aging markers.

Integrative omics approach to identify the molecular architecture of inflammatory protein levels in healthy older adults

This study identifies genetic and epigenetic factors associated with inflammatory protein levels in older adults using GWAS and EWAS with a Bayesian framework.