Author

Michael Sean Pepper

South African Medical Research CouncilORCID 0000-0001-6406-2380Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Augustinus J. van ZyliD· 1 shared J. P. de VilliersiD· 1 shared Johan W. ViljoeniD· 1 shared Marlene B. van HeerdeniD· 1 shared Massimo MezzavillaiD· 1 shared Melvin Anyasi AmbeleiD· 1 shared Reabetswe R. Pitere· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 9 mutual co-author links

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1 shared paperGenetics

Augustinus J. van ZylORCID

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2 papers

Recent·Most cited

GeneticsBiologyPeer-reviewedFeb 15, 2022

Slc7a8 deletion is protective against diet-induced obesity and attenuates lipid accumulation in multiple organs

Reabetswe R. Pitere, Marlene B. van Heerden, Michael Sean Pepper, Melvin Anyasi Ambele

This study shows that deleting SLC7A8 in mice protects against diet-induced obesity by reducing lipid accumulation in multiple organs and improving glucose metabolism.

24 citationstop 5%

mousebulk RNA-seq

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GeneticsScientific ReportsPeer-reviewedJul 17, 2019

Establishment and equilibrium levels of deleterious mutations in large populations

Johan W. Viljoen, J. P. de Villiers, Augustinus J. van Zyl…·Michael Sean Pepper

The paper models mutation dispersion in populations, estimating selective advantages using Dunbar's number and observed mutation prevalence.

2 citations

humanstatistical model

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