Chang‐Han Lee

This paper introduces a staged approach to Fab discovery by sequentially enriching heavy-chain variants and remating them with light-chain repertoires to overcome combinatorial complexity in antibody library screening.

This paper introduces Protea-Tac, a Ub-independent protein degrader that targets proteins to the proteasome, demonstrating in vivo tumor suppression.

This study uses Fc-engineered antibodies to selectively engage FcγRIIa or FcγRI, revealing their distinct effector functions in human monocytes and macrophages.

The paper develops a workflow combining immune yeast Fab display with focused humanization to identify binding-positive humanized anti-Aβ antibodies in a single sorting round.

This study shows Fc-silencing mutations in therapeutic antibodies do not block FCRL5 binding, potentially affecting B cell function through novel Fc-FCRL5 interactions.

This paper develops a method to create CAR-NK cells resistant to antigen shedding using circRNA and a novel scFv, showing comparable in vivo efficacy to lentiviral CAR-NK cells.