Adam Graham Grieve

This study identifies RHBDL2 as a rhomboid protease that enables synapse remodelling by diffusing across the neuronal membrane to cleave transmembrane adhesion molecules.

This study benchmarks AI-generated structural ensembles of membrane proteins against physics-based modeling, showing BioEmu can generate plausible conformations for large membrane proteins with lower computational cost.

The paper investigates alternative import pathways and destinations of PINK1 in mitochondria, revealing structural plasticity of its trans-membrane domain that influences its fate.

This study uses AI and simulations to analyze human rhomboid proteases, revealing that orphan members have narrower gates requiring more energy to open, explaining their substrate limitations.