David T. Blake

Daily intermittent basal forebrain stimulation improves working memory in senescent monkeys and retains benefits over time.

This study examines how different DBS parameters affect cortical acetylcholine levels and shows that peak responses are insensitive to frequency but increase with longer stimulation and donepezil treatment.

The paper shows that α7 nicotinic acetylcholine receptors are required for basal forebrain activation to increase TrkA expression, but not for BACE1 decreases in 5xFAD mice.

This study shows that stimulating cholinergic pathways in 5xFAD mice improves cognition, increases neurotrophin receptors, and reduces Aβ42 levels in the cerebral cortex.

This study shows that neural changes from working memory training transfer to untrained tasks in monkeys, revealing a neural basis for task-general cognitive benefits.

This study shows that nucleus basalis stimulation improves working memory by stabilizing attractor networks in the prefrontal cortex without increasing neural selectivity.