Engineering gene overlaps to sustain genetic constructs in vivo
Antoine L. Decrulle, Antoine Frénoy, Thomas A. Meiller-Legrand, Aude G. Bernheim, Chantal Lotton, Arnaud Gutierrez, Ariel B. Lindner
The paper designs gene overlaps to stabilize synthetic circuits in E. coli by preventing loss-of-function mutations through evolutionary constraints.
PLoS Computational Biology · Oct 8, 2021Peer-reviewedSynthetic Biology