Author

Antoine L. Decrulle

Eligo Bioscience (France)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Synthetic Biology· 3

Signature Assays, Organisms & Methods

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Organism:E. coli· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Ariel B. LindneriD· 2 shared Adeline MalletiD· 1 shared Andreas K. BrödeliD· 1 shared Antoine FrénoyiD· 1 shared Antonina O. KrawczykiD· 1 shared Arnaud GutierreziD· 1 shared Aude G. BernheimiD· 1 shared Aurélie Grienenberger· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersSynthetic Biology

Ariel B. LindnerORCID

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Author profile →

3 papers

Recent·Most cited

Treatment of STEC infection via CRISPR-Cas targeted cleavage of the Shiga toxin gene in animal models

Matthieu Galtier, Antonina O. Krawczyk, Fabien J. Fuche, Loïc H. Charpenay, Igor Stzepourginski, Simone Pignotti, Marion Arraou, Rémi Terrasse, Andreas K. Brödel, Chloé Poquet, Gautier Prevot, Dalila Spadoni, Benjamin Buhot, Kristin Munch, Jan Havránek, , Jesús Fernández-Rodríguez

This paper develops a CRISPR-based therapy targeting Shiga toxin genes in STEC infections, showing efficacy in reducing bacterial load and mitigating disease in animal models.

bioRxiv · Feb 28, 2025 · PreprintSynthetic Biology

Engineering gene overlaps to sustain genetic constructs in vivo

Antoine L. Decrulle, Antoine Frénoy, Thomas A. Meiller-Legrand, Aude G. Bernheim, Chantal Lotton, Arnaud Gutierrez, Ariel B. Lindner

The paper designs gene overlaps to stabilize synthetic circuits in E. coli by preventing loss-of-function mutations through evolutionary constraints.

PLoS Computational Biology · Oct 8, 2021Peer-reviewedSynthetic Biology

Spatial engineering of E. coli with addressable phase-separated RNAs

Haotian Guo, Joseph C. Ryan, Adeline Mallet, Xiaohu Song, Victor Pabst, Antoine L. Decrulle, Ariel B. Lindner

This paper introduces TEARS, synthetic microdomains in E. coli that enable spatial control of biochemical processes through phase-separated RNA structures.

bioRxiv · Jul 2, 2020 · PreprintSynthetic Biology