Antoine Frénoy

Emergence of mutants in bacterial populations: a simulation-based approach for parameter inference in extended Luria & Delbru&x0308;ck scenarios

This paper introduces a simulation-based method to infer mutation rates and fitness effects in bacterial populations, accounting for ecological complexities not handled by traditional models.

Evolution of mutation rates in digital genomes: the roles of genetic drift, mutational supply, and genome size

This study uses a digital genomics simulation to show that mutation rates decrease over time due to genetic drift and limited supply of fidelity-improving mutations, while genome size increases as a trade-off.

Beyond binding motif: genomic context predicts transcription factor dependent regulation in Arabidopsis

This study predicts effective transcriptional regulation by the Arabidopsis TF LFY by analyzing genomic context and binding site features.

Engineering gene overlaps to sustain genetic constructs in vivo

The paper designs gene overlaps to stabilize synthetic circuits in E. coli by preventing loss-of-function mutations through evolutionary constraints.