Ariel B. Lindner

This study creates a synthetic cell-free system where T7 phages infect synthetic cells, demonstrating a complete viral life cycle in vitro.

This paper describes open educational resources for teaching molecular biology techniques using locally produced reagents, open-source hardware, and free software, demonstrating their effectiveness in remote and low-resource settings.

qByte is an open-source, affordable fluorimeter that performs reliable biological tests in various settings, validated through real-world applications.

CodonTransformer optimizes DNA sequences for protein expression across species by learning from natural codon usage patterns and generating sequences with appropriate regulatory features.

This paper introduces Phaseek, a hybrid model for predicting and generating phase-separating protein regions, achieving 70% success in vivo peptide design.

The paper introduces PHEIGES, a method to rapidly engineer and select phages using cell-free transcription-translation, producing high titers of engineered phages within one day.

This study demonstrates the production of bioplastic PHB in engineered E. coli using CO2 and formate via the reductive glycine pathway, showing potential for electro-bioproduction.

The paper measures damage dynamics in individual E. coli cells under carbon starvation and finds that stochastic noise amplification, not initial conditions, drives lifespan variation, with increasing determinism over time.

The paper designs gene overlaps to stabilize synthetic circuits in E. coli by preventing loss-of-function mutations through evolutionary constraints.

The paper uses engineered E. coli to screen for Mtb inhibitors, identifying benazepril as an anti-mycobacterial drug with a novel mechanism.

The paper introduces MindLogger, an open-source platform for creating mobile mental health assessments and interventions, demonstrating its use in a large-scale study.

The paper designs universal riboregulators using deep learning to predict RNA sequences that suppress CRISPR-Csy4-mediated pre-crRNA processing.

This paper introduces TEARS, synthetic microdomains in E. coli that enable spatial control of biochemical processes through phase-separated RNA structures.

The paper introduces Seq2DFunc, a 2D CNN for predicting nucleic acid sequence functions from synthetic data, showing improved performance over 1D CNNs with smaller datasets.

The paper systematically detects amino acid substitutions in proteomes using mass spectrometry data and reveals that translation errors are primarily caused by codon-anticodon mispairing, with patterns influenced by ribosome velocity and evolutionary constraints.

The paper shows that senescence in Escherichia coli is shaped by two stochastic processes: random cellular deterioration and asymmetric transmission of an unknown factor during cell division.