Author

Christian A. Shively

Washington University in St. LouisORCID 0000-0001-6485-6658Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:yeast· 2 Organism:human· 1

Frequent Co-Authors

Michael R. BrentiD· 2 shared Robi David MitraiD· 2 shared Bernd J. WranikiD· 1 shared Chase MateusiakiD· 1 shared Eric JiaiD· 1 shared Griffin Kim· 1 shared Guochen LiaoiD· 1 shared Jessica N Plaggenberg· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersGenomics

Michael R. BrentORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintJan 20, 2026

Ubiquitous functional synergy partially explains why most transcription factor binding is non-functional

Chase Mateusiak, Eric Jia, Jessica N Plaggenberg…·Michael R. Brent

The paper shows that functional synergy between transcription factors explains why most TF binding does not affect gene expression, and highlights the need for more expressive regulatory network models.

1 citation

yeastChIP-seq

𝕏 PostBluesky

GenomicsGenome ResearchPeer-reviewedMar 1, 2020

MAPPING TRANSCRIPTION FACTOR NETWORKS BY COMPARING TF BINDING LOCATIONS TO TF PERTURBATION RESPONSES

Yiming Kang, Nikhil Patel, Christian A. Shively…·Michael R. Brent

The paper improves transcription factor network mapping by combining dual threshold optimization, NetProphet 2.0, and new methods for binding and response data.

29 citations

yeasthuman

𝕏 PostBluesky