Bernd J. Wranik

This study shows that GIMAP6 loss leads to inflammatory vasculopathy and atherosclerosis, causing heart failure and early death, and identifies GIMAP6 as a protective factor against cardiovascular disease.

This study uses heterochronic myeloid cell replacement to show that the local brain environment, not intrinsic factors, drives microglia aging.

The paper improves transcription factor network mapping by combining dual threshold optimization, NetProphet 2.0, and new methods for binding and response data.

The paper introduces a method to infer genome-wide regulatory causality using time-resolved gene expression data from yeast and validates its predictions experimentally.

The paper introduces a new platform to study aging yeast by purifying old cells and analyzing their transcriptional and chromatin changes.