Yiming Kang

Predicting which genes will respond to perturbations of a TF: TF-independent properties of genes are major determinants of their responsiveness

The paper predicts gene responses to TF perturbations using TF-independent features, finding that gene expression level and variation are more predictive than TF binding or histone marks.

MAPPING TRANSCRIPTION FACTOR NETWORKS BY COMPARING TF BINDING LOCATIONS TO TF PERTURBATION RESPONSES

The paper improves transcription factor network mapping by combining dual threshold optimization, NetProphet 2.0, and new methods for binding and response data.

Neutrophil adhesion in brain capillaries contributes to cortical blood flow decreases and impaired memory function in a mouse model of Alzheimer’s disease

This study identifies neutrophil adhesion in brain capillaries as a cause of reduced cerebral blood flow and impaired memory in an Alzheimer's mouse model, showing that targeting this adhesion improves both CBF and memory.