Author

Lea Klingenberg Barfod

University of OxfordORCID 0000-0001-6510-495XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:rat· 2 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Amelia M. LiasiD· 2 shared Doris QuinkertiD· 2 shared Ivan CampeottoiD· 2 shared Lloyd D. W. King· 2 shared Matthew K. HigginsiD· 2 shared Simon J. DraperiD· 2 shared Alexander D. DouglasiD· 1 shared Amy R. NoeiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersImmunology

Amelia M. LiasORCID

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3 papers

Recent·Most cited

BiophysicsNature CommunicationsPeer-reviewedAug 5, 2025

Cryo-EM led analysis of open and closed conformations of Chagas vaccine candidate TcPOP and its antibody response characterisation

Sagar Batra, Francisco Olmo, Timothy J. Ragan…·Ivan Campeotto

This study determines the 3D structures of TcPOP in open and closed conformations using cryo-EM and evaluates its immunogenicity through antibody responses in mice.

2 citations

cryo-EMexperimental assay

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ImmunologyEMBO Molecular MedicinePeer-reviewedSep 2, 2024

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

Thomas E. Harrison, Nawsad Alam, Brendan Farrell…·Matthew K. Higgins

This paper designs a malaria vaccine immunogen using structure-guided methods to present a single epitope from PfRH5, showing improved antibody response in rats compared to PfRH5 alone.

12 citations

ratprotein structure

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ImmunologyNature CommunicationsPeer-reviewedJun 7, 2024

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

Barnabas G. Williams, Lloyd D. W. King, David Pulido…·Simon J. Draper

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

34 citationstop 1%

ratproteomics

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