Matthew K. Higgins

This paper describes the structure of HpBARI2, a helminth-derived protein that trimerises to selectively inhibit membrane-bound ST2 receptor signaling by blocking IL-33 binding and preventing co-receptor recruitment.

This study investigates the evolutionary adaptation of helminth immunomodulators by analyzing the ARI family in different nematode species and their interactions with host IL-33 and heparan sulphate.

This study characterizes antibodies against PfRIPR, showing that inhibitory antibodies induce conformational changes in the PfRIPR tail during erythrocyte invasion.

The paper identifies a T. brucei surface protein that inhibits the complement system by blocking the C3bBb convertase.

The paper identifies a gene variant in Trypanosoma brucei gambiense that confers resistance to human serum, explaining how this subspecies evades trypanolytic factors.

The paper presents the first chromosome-scale genome assembly for Dermacentor reticulatus, revealing a repeat-rich genome and providing insights into its phylogenetic placement and functional genomics.

This study shows GPI-anchored receptors in Trypanosoma brucei are localized across the entire cell surface, not just the flagellar pocket, challenging previous assumptions about immune evasion.

The paper shows RIFINs of Plasmodium falciparum bind LILRB1 in different conformations, triggering inhibitory signaling either in trans or cis to suppress immune responses.

This study determines the structure of the Entamoeba histolytica Gal/GalNAc lectin, revealing its carbohydrate binding mechanism and antibody epitope, which informs vaccine development.

The paper identifies a helminth-derived CCP domain protein, HpBoRB, that binds RELMβ, a host protein with anti-helminth properties, suggesting a mechanism of immune evasion.

This study shows CD163 forms multimeric complexes to recognize diverse haemoglobin-haptoglobin ligands, enabling detoxification.

The paper identifies RIFINs that bind both inhibitory and activating KIR receptors, revealing their role in modulating NK cell activation during malaria infection.

TOAST optimises amplicon design for tuberculosis genomic studies, enabling high-throughput sequencing of drug resistance mutations across multiple platforms.

This paper designs a malaria vaccine immunogen using structure-guided methods to present a single epitope from PfRH5, showing improved antibody response in rats compared to PfRH5 alone.

The paper shows that DNA and heparan sulphate binding prolongs the in vivo half-life of HpARI1 and HpARI2 proteins compared to HpARI3.

This study designs an improved PvDBP-based immunogen using structure-guided methods to enhance its stability and antibody response against Plasmodium vivax.

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

The paper develops an online immuno-analytics tool to analyze SARS-CoV-2 genetic and immunological data, identifying mutation trends and potential diagnostic targets.