BiochemistryMolecular CellPeer-reviewed
Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer
Yasushi Kondo, Judith Notbohm, Ignacio Navas Camacho…·Tina Perica
The paper presents the first X-ray structure of an NtA-mediated asymmetric BRAF dimer bound to MEK1, showing it is a catalytically active state, not an intermediate in BRAF activation.
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