Author

Thomas J. Mason

Paul Scherrer InstituteORCID 0009-0002-7823-6497Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:structural biology· 3 Organism:human· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

J. StandfussiD· 2 shared John H. BealeiD· 2 shared Martin V. ApplebyiD· 2 shared Yasushi KondoiD· 2 shared Amadeu LlebariaiD· 1 shared Anna Duran‐CorberaiD· 1 shared Annica SaaretiD· 1 shared Antoine RoyantiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

J. StandfussORCID

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3 papers

Recent·Most cited

Mechanism of MEK1 phosphorylation by the N-terminal acidic motif mediated asymmetric BRAF dimer

Yasushi Kondo, Judith Notbohm, Ignacio Navas Camacho, Gabriela Nagy‐Davidescu, Thomas J. Mason, Jonas Mühle, J. Standfuss, Tina Perica

The paper presents the first X-ray structure of an NtA-mediated asymmetric BRAF dimer bound to MEK1, showing it is a catalytically active state, not an intermediate in BRAF activation.

Molecular Cell · Jul 21, 2026Peer-reviewedBiochemistry

Integrated structural dynamics uncover new modes of B12 photoreceptor activation

Ronald Rios-Santacruz, Harshwardhan Poddar, Kévin Pounot, Derren J. Heyes, Nicolas Coquelle, Megan J. Mackintosh, Linus O. Johannissen, Sara Schianchi, Laura N. Jeffreys, Elke De Zitter, Rory Munro, Martin V. Appleby, Danny Axford, Emma V. Beale, Matthew J. Cliff, , Giorgio Schirò

The paper describes the photoactivation mechanism of the B12 photoreceptor CarH using structural and spectroscopic methods, revealing unique intermediates that drive tetramer dissociation.

Nature · Feb 4, 2026Peer-reviewedBiophysics

Time-resolved structures of β2-adrenergic receptor modulation by a photoswitchable beta-blocker

Robin Stipp, Quentin Bertrand, Matilde Cardoso Trabuco, Anna Duran‐Corbera, Maria Tindara Ignazzitto, Hannah Glover, Fabienne Stierli, Juanlo Catena, Melissa Carrillo, Sina Hartmann, Hans Peter Seidel, Matthias Mulder, Thomas J. Mason, Yasushi Kondo, Maximilian Wranik, , J. Standfuss

This study captures time-resolved structures of β2AR modulated by a photoswitchable beta-blocker, revealing conformational changes linked to ligand isomerization and receptor function.

bioRxiv · Sep 3, 2025 · PreprintBiochemistry