Liyu Huang

The paper identifies a metastasis-initiating-like state in prostate cancer linked to FEV, tumor plasticity, and immune niche remodeling through integrated multi-omics analysis.

Spatium is a foundation model for spatial proteomics that learns stable cell representations from constrained protein measurements, enabling accurate cell identity recovery and spatial microenvironment analysis.

This paper introduces scMIC, a computational framework for identifying metastasis-initiating cells from single-cell data, validated across multiple cancer types and datasets.

This study benchmarks 29 RNA velocity algorithms across simulated and real scRNA-seq datasets, highlighting performance variations and practical constraints.

The paper identifies 14 metastasis-related mutated genes and develops a Mscore to predict metastatic risk in primary prostate tumors using xgboost.

This study investigates how A-to-I RNA editing affects cancer immunity by modulating interferon pathways and immune cell infiltration.

The paper identifies 25 RNA editing biomarkers in Parkinson's disease by analyzing their potential impact on miRNA regulations of 133 PD-related genes.

The paper identifies 24,236 potentially functional A-to-I RNA editing events across 33 cancer types from The Cancer Genome Atlas, linking them to tumorigenesis through altered expression, protein function, and miRNA regulation.

The paper identifies genetic variants influencing A-to-I RNA editing in neurodegenerative diseases using large-scale transcriptomic and genetic data from multiple brain tissues.

The paper identifies APA events associated with TNBC prognosis, highlighting a novel biomarker in UBASH3B that affects microRNA regulation.