Author

Sijia Wu

Xidian UniversityORCID 0000-0002-2863-6065Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 9 Approach:statistical model· 9 Research Focus:differential expression· 8 Assay:bulk RNA-seq· 7 Research Focus:gene regulatory network inference· 4 Research Focus:cell type annotation· 3 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Liyu HuangiD· 9 shared Xiaobo ZhouiD· 7 shared Pora KimiD· 5 shared Mengyuan YangiD· 3 shared Jiangpeng WeiiD· 2 shared Jianguo WeniD· 2 shared Qiuping Xue· 2 shared Xiaoming WuiD· 2 shared

Activity by Year

2020-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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9 shared papersBioinformatics

Liyu HuangORCID

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

An FEV-Associated Metastasis-Initiating-Like State Linked to Tumor Cell Plasticity and Immune Niche Remodeling in Prostate Cancer

Sijia Wu, Jiangpeng Wei, Xiaorui Shi, Xin Liu, Xiaobo zhou, Liyu Huang

The paper identifies a metastasis-initiating-like state in prostate cancer linked to FEV, tumor plasticity, and immune niche remodeling through integrated multi-omics analysis.

bioRxiv · Sep 29, 2026 · PreprintBioinformatics

Spatium: A Protein Language Foundation Model for Spatial Proteomics

Tiangang Wang, Sijia Wu, Liyu Huang, Jiajia Liu, Kexin Huang, Xiaobo Zhou

Spatium is a foundation model for spatial proteomics that learns stable cell representations from constrained protein measurements, enabling accurate cell identity recovery and spatial microenvironment analysis.

bioRxiv · Jul 26, 2026 · PreprintBioinformatics

Identification and Characterization of Metastasis-initiating cells

Sijia Wu, Jiangpeng Wei, Xin Liu, Jiajin Zhang, Jianguo Wen, Liyu Huang, Xiaobo Zhou

This paper introduces scMIC, a computational framework for identifying metastasis-initiating cells from single-cell data, validated across multiple cancer types and datasets.

bioRxiv · Feb 6, 2026 · PreprintBioinformatics

Heterogeneity and genomic evolution of metastatic prostate cancer

Sijia Wu, Zhennan Lu, Yanfei Wang, Xiaobo Zhou, Liyu Huang

The paper identifies 14 metastasis-related mutated genes and develops a Mscore to predict metastatic risk in primary prostate tumors using xgboost.

bioRxiv · Sep 1, 2023 · PreprintBioinformatics

The roles of RNA editing in cancer immunity through interacting with interferon

Sijia Wu, Xinyu Qin, Zhennan Lu, Jianguo Wen, Mengyuan Yang, Pora Kim, Xiaobo Zhou, Liyu Huang

This study investigates how A-to-I RNA editing affects cancer immunity by modulating interferon pathways and immune cell infiltration.

bioRxiv · Aug 6, 2023 · PreprintBioinformatics

The Potential Regulation of A-to-I RNA editing on Genes in Parkinson's Disease

Sijia Wu, Qiuping Xue, Xinyu Qin, Xiaoming Wu, Pora Kim, Jacqueline Chyr, Xiaobo Zhou, Liyu Huang

The paper identifies 25 RNA editing biomarkers in Parkinson's disease by analyzing their potential impact on miRNA regulations of 133 PD-related genes.

Genes · Apr 15, 2023Peer-reviewedBioinformatics

The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers

Sijia Wu, Zhiwei Fan, Pora Kim, Liyu Huang, Xiaobo Zhou

The paper identifies 24,236 potentially functional A-to-I RNA editing events across 33 cancer types from The Cancer Genome Atlas, linking them to tumorigenesis through altered expression, protein function, and miRNA regulation.

Genomics Proteomics & Bioinformatics · Jan 25, 2023Peer-reviewedBioinformatics

Genetic control of RNA editing in Neurodegenerative disease

Sijia Wu, Qiuping Xue, Mengyuan Yang, Yanfei Wang, Pora Kim, Xiaobo Zhou, Liyu Huang

The paper identifies genetic variants influencing A-to-I RNA editing in neurodegenerative diseases using large-scale transcriptomic and genetic data from multiple brain tissues.

Briefings in Bioinformatics · Jan 2, 2023Peer-reviewedBioinformatics

Alternative Polyadenylation alters UBASH3B-ZNF652 competition to involve in Triple-Negative Breast Cancer

Sijia Wu, Changbao Hu, Xiaoming Wu, Xiaobo Zhou, Liyu Huang

The paper identifies APA events associated with TNBC prognosis, highlighting a novel biomarker in UBASH3B that affects microRNA regulation.

bioRxiv · Dec 27, 2022 · PreprintBioinformatics

A novel bioinformatics approach to reveal the role of circadian oscillations in AD development

Zhiwei Ji, Dazhi Shang, Pora Kim, Mengyuan Yang, Sijia Wu, Weiling Zhao, Eunju Kim, Marvin Wirianto, Zheng Chen, Seung Hee Yoo, Xiaobo Zhou

This study introduces ESOCVD, a computational platform to detect circadian gene expression patterns in AD using untimed transcriptome data, revealing five circadian alteration patterns in AD patients.

bioRxiv · Jul 16, 2020 · PreprintBioinformatics