Jianguo Wen

Systematic Benchmarking of AI-Based Molecular Generation Models for Structure-Based Drug Design

This study benchmarks 12 AI-based molecular generation models for drug design across 176 protein-ligand systems, finding no single method optimizes all criteria and proposing a hybrid approach.

Identification and Characterization of Metastasis-initiating cells

This paper introduces scMIC, a computational framework for identifying metastasis-initiating cells from single-cell data, validated across multiple cancer types and datasets.

A Cell Cycle-aware Network for Data Integration and Label Transferring of Single-cell RNA-seq and ATAC-seq

The paper introduces CCAN, a model that removes cell cycle effects from integrated single-cell multi-omics data while preserving cell type-specific variations, showing strong performance in downstream tasks.

The roles of RNA editing in cancer immunity through interacting with interferon

This study investigates how A-to-I RNA editing affects cancer immunity by modulating interferon pathways and immune cell infiltration.