Daniel R. Semlow

This study shows HMCES-DPC formation increases DNA template flexibility, enabling slippage and mutagenic bypass of AP sites during replication.

This study investigates how the Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links using Xenopus egg extracts.

This study shows ATM kinase promotes reversed fork resection during ICL repair, dependent on EXO1 and DNA2 nucleases, and reveals PP2A's role in regulating this process.

This study identifies catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis using CRISPR screening and TLS analysis.

This study shows that HMCES-DPC forms as a constitutive intermediate in replication-coupled DNA repair, suppressing DSBs and influencing TLS.