HMCES DNA-protein cross-links promote template slippage during DNA replication
He Xu, Yixin Clem Xu, Yuge Chai, Kha The Nguyen, Gaoyuan Liu, William A. Goddard, Daniel R. Semlow
This study shows HMCES-DPC formation increases DNA template flexibility, enabling slippage and mutagenic bypass of AP sites during replication.
bioRxiv · Aug 19, 2026 · PreprintBiochemistry