This study identifies MRE11A as a negative regulator of human DNA mismatch repair, showing its role in modulating DNA damage signals and MMR activity through interactions with MLH1 and PMS2.

Cellular & Molecular Biology Letters · Mar 14, 2024Peer-reviewedMolecular Biology

Paternal methamphetamine exposure induces higher sensitivity to methamphetamine in male offspring through driving ADRB1 on CaMKII-positive neurons in mPFC

Yanyan Zheng, Dekang Liu, Hao Guo, Wenwen Chen, Zhaoyu Liu, Zhaosu Li, Tao Hu, Yuanyuan Zhang, Xiang Li, Ziheng Zhao, Qinglong Cai, Feifei Ge, Yu Fan, Xiaowei Guan

Translational Psychiatry · Oct 19, 2023Peer-reviewedNeuroscience

Electro-acupuncture Alleviates METH Withdrawal-induced Spatial Memory Deficits by Restoring Astrocyte-drived Glutamate Uptake in dCA1

Pengbo Shi, Zhaosu Li, Xing Xu, Jiaxun Nie, Dekang Liu, Qinglong Cai, Yonghua Zhao, Yun Guan, Feifei Ge, Xiaowei Guan

This study shows electro-acupuncture restores astrocyte-driven glutamate uptake in dCA1, reducing hyper-glutamatergic excitotoxicity and improving spatial memory deficits in METH withdrawal mice.

bioRxiv · May 20, 2020 · PreprintNeuroscience