Xiaowei Guan

This study identifies MRE11A as a negative regulator of human DNA mismatch repair, showing its role in modulating DNA damage signals and MMR activity through interactions with MLH1 and PMS2.

The paper identifies two distinct eLPBChAT projections to the amygdala and bed nucleus of the stria terminalis that mediate methamphetamine withdrawal anxiety and relapse.

This study identifies the role of claustrum D1RCaMKII in adolescent cocaine exposure-induced anxiety-like behaviors and shows that electro-acupuncture can alleviate these behaviors by targeting this pathway.

The paper identifies distinct roles of claustrum subregions in anxiety and cocaine addiction susceptibility following adolescent cocaine exposure.

The paper shows that adolescent cocaine exposure increases adult cocaine sensitivity via DUSP1 on CaMKII-positive neurons in mPFC, and manipulating DUSP1 affects this sensitivity.

The paper identifies a cerebellar pathway that blocks METH-induced conditioned place preference in mice without affecting motor function.

The paper identifies a novel cholinergic pathway from eLPBChAT to CeAGABA that blocks methamphetamine-induced conditioned place preference in mice.

This study shows electro-acupuncture restores astrocyte-driven glutamate uptake in dCA1, reducing hyper-glutamatergic excitotoxicity and improving spatial memory deficits in METH withdrawal mice.