Yun Guan

The paper identifies neurotrophic signals, particularly FGF9, required for fracture healing by mapping somatosensory afferent circuitry to bone and analyzing gene expression changes in DRG neurons.

This study shows that TrkA+ sensory neurons promote osteosarcoma progression by enhancing tumor growth, vascularization, and metastasis, and that inhibiting these neurons reduces disease severity and improves survival.

The paper develops a pipeline for high-resolution imaging and analysis of whole mouse glomeruli, revealing novel aging and disease-related phenotypes.

The paper demonstrates that human amniotic membrane products inhibit post-surgical pain in mice through CD44-dependent pathways and cytoskeleton rearrangements in nociceptive neurons.

This study shows Ezh2 promotes axon regeneration in the PNS and CNS by epigenetically regulating genes involved in regeneration and inhibitory signaling.

The paper uses scRNA-seq to identify subtype-specific transcriptomic changes in DRG neurons of Pirt-EGFPf mice under neuropathic pain conditions.

The paper identifies cis-regulatory elements in dorsal root ganglion neurons that show differential chromatin accessibility and TF binding after nerve injury, linking them to chronic pain.

The paper identifies transcriptomic and epigenetic changes in rat dorsal root ganglia under two chronic pain models, revealing shared and distinct chromatin accessibility alterations.

This study shows electro-acupuncture restores astrocyte-driven glutamate uptake in dCA1, reducing hyper-glutamatergic excitotoxicity and improving spatial memory deficits in METH withdrawal mice.

This study shows that MCT1 in Schwann cells is essential for maintaining sensory nerve myelination during aging, leading to hypomyelination and impaired function.

The paper identifies sex-related gene expression differences in the dorsal root ganglion of male and female rats after nerve injury using RNA-seq.