Molecular BiologyScientific ReportsPeer-reviewed
Targeting collagen biosynthesis by small molecules inhibiting the function of the peptide-substrate-binding domain of collagen prolyl 4-hydroxylases
Bukunmi Adediran, Carlos Vela‐Rodríguez, Sudarshan Murthy…·M. Kristian Koski
The paper develops a FRET-based assay to identify small molecules that inhibit collagen prolyl 4-hydroxylases by targeting their peptide-substrate-binding domain, leading to the discovery of a selective inhibitor.
DOI 10.1038/s41598-026-53109-y