M. Kristian Koski

The paper develops a FRET-based assay to identify small molecules that inhibit collagen prolyl 4-hydroxylases by targeting their peptide-substrate-binding domain, leading to the discovery of a selective inhibitor.

This study shows ADP-bound mtHSP70 binds preferentially to GRPEL1 over GRPEL2, with structural insights into their functional differences.

This study identifies sequence specificity of collagen prolyl 4-hydroxylase isoenzymes for different X-Pro-Gly triplets and their impact on collagen stability and assembly.